Lorrca RUO

During the Osmoscan, Lorrca measures deformability under an osmotic gradient and shows the cell’s condition at different osmotic values. This scan is used to study hereditary anemias, membrane disorders, enzyme deficiencies, thalassemia and Sickle Cell Disease.

With an Osmoscan, four parameters are defined that are important to characterize the “fitness” of the RBCs: Omin (osmolality at Elmin, hypotonic region), Elmax (maximal oEL of the total curve), Omax (osmolality at Elmax) and Ohyper (osmolality corresponding to 50% of the Elmax; hypertonic region).

An Oxygenscan is a distinctive technique to measure and visualize RBC elongation in shear stress in an oxygen gradient. Lorrca is used to perform this scan for Sickle Cell Disease studies and Sickle Cell Anemia treatment development.

During the Oxygenscan, Lorrca measures the relative oxygen pressure at the “Point of Sickling”’, often referred to as “PoS”. This is a critical point where the RBCs of the sickle cell patient starts to become rigid and crescent. The PoS for a sickle patient is indicative of the current SCD severity, that’s why the fast results of each test is an important feature of Lorrca.

RBC aggregation is an important, shear dependent, determinant of blood viscosity. The Lorrca aggregation and disaggregation application is used to study infectious diseases, blood storage and blood quality and to detect diseases like inflammatory states, vascular pathologies and tissue perfusion problems.